Anti-rheumatoid Activity of Secondary Metabolites Produced by Endophytic Chaetomium globosum

@article{AbdelAzeem2016AntirheumatoidAO,
  title={Anti-rheumatoid Activity of Secondary Metabolites Produced by Endophytic Chaetomium globosum},
  author={Ahmed M. Abdel-Azeem and S. Zaki and W. Khalil and Noha A. Makhlouf and L. M. Farghaly},
  journal={Frontiers in Microbiology},
  year={2016},
  volume={7}
}
The aim of the present study was to investigate the anti-rheumatoid activity of secondary metabolites produced by endophytic mycobiota in Egypt. A total of 27 endophytic fungi were isolated from 10 dominant medicinal plant host species in Wadi Tala, Saint Katherine Protectorate, arid Sinai, Egypt. Of those taxa, seven isolates of Chaetomium globosum (CG1–CG7), being the most frequent taxon, were recovered from seven different host plants and screened for production of active anti-inflammatory… Expand
Antiviral and Antioxidant Potential of Fungal Endophytes of Egyptian Medicinal Plants
TLDR
The results indicate that the endophytic fungi from medicinal plants are promising sources of bioactive compounds and can be attributed to antiviral activates. Expand
Endophytic fungal research in Egypt: Present status
TLDR
The role of most brilliant Egyptian researchers to generate potentially valuable products by using native endophytic fungi and the present status ofendophytic fungal research in Egypt are illustrated. Expand
Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review
  • R. Toghueo
  • Medicine
  • Natural Products and Bioprospecting
  • 2019
TLDR
The status of research from 2000 to 2019 on the anti-leishmanial and anti-inflammatory metabolites isolated from endophytes from diverse habitats is reviewed to help accelerate the drug discovery against leishmaniases and inflammation-associated disorders. Expand
Endophytic fungi: A gold mine of antioxidants
Endophytic fungi residing in medicinal plants have the ability to produce the same pharmacologic bioactive secondary metabolites as their host medicinal plants, which have been used for thousands ofExpand
Mycogenic Silver Nanoparticles from Endophytic Trichoderma atroviride with Antimicrobial Activity
There is an increasing interest in developing nanoparticles with diverse biologic activities. To this end, we prepared 10 to 15 nm silver nanoparticles (AgNP) from native isolates of TrichodermaExpand
Diversity of the culturable endophytic fungi producing L-asparaginase in arid Sinai, Egypt
TLDR
The present study suggests that L. theobromae has the potential to be used as an alternative and reliable source of L-asparaginase for potent anticancer agents. Expand
Elucidating Mechanisms of Endophytes Used in Plant Protection and Other Bioactivities With Multifunctional Prospects
TLDR
This study elucidates the mechanisms employed by endophytes in protecting the plant from diseases and different bioactivities of importance to humans with a focus on endophytic bacteria and fungi. Expand
Isolation of taxol producing endophytic fungus Alternariabrassicicola from non-Taxus medicinal plant Terminalia arjuna
TLDR
Results suggest that the endophytic fungus A.brassicicola serves as a potential source for the production of taxol isolated from non-Taxus plant. Expand
Endophytic fungi: A new strategy to conserve medicinal plants in Jordan
Jordan contains approximately 2,500 species of plants distributed throughout the Kingdom, from these species there are 485 species belonging to 99 different families are categorized as medicinalExpand
Chaetomium globosum extract mediated gold nanoparticle synthesis and potent anti-inflammatory activity.
TLDR
In insights into the design of nano delivery, gold nanoparticles obtained by using a fungal endophytic strain Chaetomium globosum isolated from Vitex negundo are provided and may be applied for clinical studies in future. Expand
...
1
2
...

References

SHOWING 1-10 OF 115 REFERENCES
Biological Evaluation of Endophytic Fungus, Chaetomium globosum JN711454, as Potential Candidate for Improving Drug Discovery
TLDR
It is reported for the first time inhibitory activity of endophytic C. globosum JN711454 secondary metabolites to butyrylcholinesterase, one of neuro hydrolase enzymes that play a major role in development of Alzheimer’s disease. Expand
Bioactive metabolites from the endophytic fungus Ampelomyces sp. isolated from the medicinal plant Urospermum picroides.
Extracts of cultures grown in liquid or on solid rice media of the fungal endophyte Ampelomyces sp. isolated from the medicinal plant Urospermum picroides exhibited considerable cytotoxic activityExpand
Biodiversity and antimicrobial activity of endophytes associated with Egyptian medicinal plants
TLDR
One-hundred and thirty-two endophytic strains were isolated from 18 medicinal plants from Saint Katherine Protectorate, Egypt and showed a broad spectrum of inhibitory activity against different pathogenic bacteria and yeasts. Expand
Koninginins, phospholipase A2 inhibitors from endophytic fungus Trichoderma koningii.
TLDR
Results, apparently, indicate that koninginins E and F, as well as vitamin E, present structural regions that might be used as start points in seeking for new and specific anti-inflammatory drugs against such enzymes. Expand
Rainforest Endophytes and Bioactive Products
  • G. Strobel
  • Biology, Medicine
  • Critical reviews in biotechnology
  • 2002
TLDR
This review discusses an approach for bio-prospecting the rainforests, not only to harvest their endophytic microorganisms, but to eventually build a better understanding of the importance and value they have to humankind. Expand
FR 207944 , an Antifungal Antibiotic from Chaetomium sp . No . 217 I . Taxonomy , Fermentation , and Biological Properties
An antifungal antibiotic, FR207944, was isolated from the culture broth of a fungal strain Chaetomium sp. no. 217. FR207944 is a triterpene glucoside with antifungal activity against AspergillusExpand
Globosumones A-C, cytotoxic orsellinic acid esters from the Sonoran desert endophytic fungus Chaetomium globosum.
Three new esters of orsellinic acid, globosumones A-C (1-3), and three known compounds, orsellinic acid (4), orcinol, and trichodion (5), were isolated from Chaetomium globosum endophytic onExpand
FR207944, an Antifungal Antibiotic from Chaetomium sp. No. 217 I. Taxonomy, Fermentation, and Biological Properties
An antifungal antibiotic, FR207944, was isolated from the culture broth of a fungal strain Chaetomium sp. no. 217. FR207944 is a triterpene glucoside with antifungal activity against AspergillusExpand
Endophytic fungi: a source of novel biologically active secondary metabolites * * Paper presented at
TLDR
It is hypothesize that the interaction fungal endophyte-plant host is characterized by a finely tuned equilibrium between fungal virulence and plant defence, and if this balance is disturbed by either a decrease in plant defence or an increase in fungalvirulence, disease develops. Expand
...
1
2
3
4
5
...