Anti-retroviral therapy with protease inhibitors decreases virulence enzyme expression in vivo by Candida albicans without selection of avirulent fungus strains or decreasing their anti-mycotic susceptibility.

@article{Bernardis2004AntiretroviralTW,
  title={Anti-retroviral therapy with protease inhibitors decreases virulence enzyme expression in vivo by Candida albicans without selection of avirulent fungus strains or decreasing their anti-mycotic susceptibility.},
  author={Flavia de Bernardis and Evelina Tacconelli and Francesca Mondello and Adriana Cataldo and Silvia Arancia and Roberto Cauda and Antonio Cassone},
  journal={FEMS immunology and medical microbiology},
  year={2004},
  volume={41 1},
  pages={27-34}
}
Highly active anti-retroviral therapies (HAART) with human immunodeficiency virus (HIV) protease inhibitors (PIs) or nonnucleoside reverse-transcriptase inhibitors (NNRTI) were compared for their effect on prevalence, aspartyl proteinase (Sap) production and the biotypes and anti-mycotic sequential susceptibility of Candida spp. isolates from the oral cavity in a longitudinal prospective study. HAART-PI, but not HAART-NNRTI strongly inhibited Sap expression in the oral cavity without exerting… CONTINUE READING