Anti-remodelling effect of canrenone in patients with mild chronic heart failure (AREA IN-CHF study): final results.

@article{Boccanelli2009AntiremodellingEO,
  title={Anti-remodelling effect of canrenone in patients with mild chronic heart failure (AREA IN-CHF study): final results.},
  author={Alessandro Boccanelli and Gian Francesco Mureddu and Giuseppe Cacciatore and Francesco Clemenza and Andrea Di Lenarda and Antonello Gavazzi and Maurizio Porcu and Roberto Latini and Donata Lucci and Aldo Pietro Maggioni and Serge Masson and Massimo Vanasia and Giovanni de Simone},
  journal={European journal of heart failure},
  year={2009},
  volume={11 1},
  pages={
          68-76
        }
}
AIMS To test whether canrenone, an aldosterone receptor antagonist, improves left ventricular (LV) remodelling in NYHA class II heart failure (HF). Aldosterone receptor antagonists improve outcome in severe HF, but no information is available in NYHA class II. METHODS AND RESULTS AREA IN-CHF is a randomized, double-blind, placebo-controlled study testing canrenone on top of optimal treatment in NYHA class II HF with low ejection fraction (EF) to assess 12-month changes in LV end-diastolic… CONTINUE READING
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