Anti-prothrombin antibodies cause thrombosis in a novel qualitative ex-vivo animal model.

@article{HajYahia2003AntiprothrombinAC,
  title={Anti-prothrombin antibodies cause thrombosis in a novel qualitative ex-vivo animal model.},
  author={Saleem Haj-Yahia and Yaniv Sherer and Miri Blank and Hiroshi Kaetsu and Aram Kurt Smolinsky and Yehuda Shoenfeld},
  journal={Lupus},
  year={2003},
  volume={12 5},
  pages={364-9}
}
Anti-prothrombin antibodies (aPT) are associated with thrombotic manifestations, and their association with reproductive failure is debatable. The aim of this study was to examine whether aPT could induce thrombosis and other clinical manifestations of the anti-phospholipid syndrome (APS). Mice were immunized with either prothrombin, beta2-glycoprotein-I (beta2GPI), or beta2GPI followed by prothrombin. The presence of clinical manifestation of APS, including thrombocytopenia, lupus… CONTINUE READING

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The presence of clinical manifestation of APS , including thrombocytopenia , lupus anticoagulant and fetal resorption rates , was evaluated in all mice groups compared with nonimmunized mice .
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