Anti-proliferative effect of rhein, an anthraquinone isolated from Cassia species, on Caco-2 human adenocarcinoma cells

@inproceedings{Aviello2010AntiproliferativeEO,
  title={Anti-proliferative effect of rhein, an anthraquinone isolated from Cassia species, on Caco-2 human adenocarcinoma cells},
  author={Gabriella Aviello and Ian John Rowland and Christopher I R Gill and Angela Maria Acquaviva and Francesco Capasso and Mark McCann and Raffaele Capasso and Angelo A Izzo and Francesca Borrelli},
  booktitle={Journal of cellular and molecular medicine},
  year={2010}
}
In recent years, the use of anthraquinone laxatives, in particular senna, has been associated with damage to the intestinal epithelial layer and an increased risk of developing colorectal cancer. In this study, we evaluated the cytotoxicity of rhein, the active metabolite of senna, on human colon adenocarcinoma cells (Caco-2) and its effect on cell proliferation. Cytotoxicity studies were performed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), neutral red (NR) and… CONTINUE READING
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