Anti-proliferative effect of levamisole on human myeloma cell lines in vitro

  title={Anti-proliferative effect of levamisole on human myeloma cell lines in vitro},
  author={M. Ramanadham and B. Nageshwari},
  journal={Journal of Immunotoxicology},
  pages={327 - 332}
Levamisole has been employed as an immunomodulatory agent in conjunction with 5-fluorouracil in the treatment of colon cancer relapse. At high doses, levamisole has been shown to have both anti-cancer and immunosuppressive activities. In vitro, levamisole has been shown to potentiate the anti-proliferative effect of 5-fluorouracil in several types of tumor cell lines; however, its mechanism of cytotoxic action and its molecular targets in cells remains to be elucidated. Here, the effect of… Expand
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