Anti-proliferative and cytotoxic activity of pentadactylin isolated from Leptodactylus labyrinthicus on melanoma cells

@article{Librio2009AntiproliferativeAC,
  title={Anti-proliferative and cytotoxic activity of pentadactylin isolated from Leptodactylus labyrinthicus on melanoma cells},
  author={Michelle da Silva Lib{\'e}rio and Graziella Anselmo Joanitti and Ricardo Bentes de Azevedo and Eduardo Maffud Cilli and Lanuse C. Zanotta and Anna Cyntia Brand{\~a}o Nascimento and Marcelo V. Sousa and Osmindo R. Pires J{\'u}nior and W. Garc{\'i}a Fontes and Mariana S. Castro},
  journal={Amino Acids},
  year={2009},
  volume={40},
  pages={51-59}
}
Nowadays, the emergence of resistance to the current available chemotherapeutic drugs by cancer cells makes the development of new agents imperative. The skin secretion of amphibians is a natural rich source of antimicrobial peptides (AMP), and researchers have shown that some of these wide spectrum molecules are also toxic to cancer cells. The aim of this study was to verify a putative anticancer activity of the AMP pentadactylin isolated for the first time from the skin secretion of the frog… CONTINUE READING
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