Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice.

@article{Kasagi2010AntiprogrammedCD,
  title={Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice.},
  author={Shimpei Kasagi and Seiji Kawano and Taku Okazaki and Tasuku Honjo and Akio Morinobu and Saori Hatachi and Kenichiro Shimatani and Yoshimasa Tanaka and Nagahiro Minato and Shunichi Kumagai},
  journal={Journal of immunology},
  year={2010},
  volume={184 5},
  pages={
          2337-47
        }
}
Programmed cell death 1 (PD-1) is an immunosuppressive receptor that transduces an inhibitory signal into activated T cells. Although a single nucleotide polymorphism in the gene for PD-1 is associated with susceptibility to systemic lupus erythematosus, the role of PD-1 in systemic lupus erythematosus is still not well understood. In this study, we used NZB/W F1 mice, a model of lupus-like nephritis, to examine the function of PD-1 and its ligands. PD-1 was predominantly expressed on CD4(+) T… CONTINUE READING
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