Anti-prion antibodies for prophylaxis following prion exposure in mice.

  title={Anti-prion antibodies for prophylaxis following prion exposure in mice.},
  author={Einar M. Sigurdsson and M Ourey Sy and Ruliang Li and Henrieta Scholtzova and Richard J. Kascsak and Regina B Kascsak and Richard I. Carp and Harry C. Meeker and Blas Frangione and Thomas Wisniewski},
  journal={Neuroscience letters},
  volume={336 3},
Prion disease is characterized by a conformational change of the normal form of the prion protein (PrP(C)) to the scrapie-associated form (PrP(Sc)). Since the emergence of new variant Creutzfeldt-Jakob disease a potentially large human population is at risk for developing prion disease. Currently, no effective treatment or form of post-exposure prophylaxis is available for prion disease. We recently showed that active immunization with recombinant PrP prolongs the incubation period of scrapie… CONTINUE READING