Anti-platelet aggregation constituents from Formosan Toddalia asiatica.

@article{Tsai1998AntiplateletAC,
  title={Anti-platelet aggregation constituents from Formosan Toddalia asiatica.},
  author={I L Tsai and Maung Wun and Che M. Teng and T Ishikawa and Ih-Sheng Chen},
  journal={Phytochemistry},
  year={1998},
  volume={48 8},
  pages={
          1377-82
        }
}
Examination on the wood of Formosan Toddalia asiatica led to the isolation of 30 compounds, including coumarins, alkaloids, a benzoquinone and an amine. Among the isolates, (+/-)-toddanin and (-)-isocoreximine are new compounds, while cyclohexylamine was isolated for the first time from nature. The structures of the compounds were elucidated from spectroscopic data and chemical evidence. Bioassay-guided fractionation led to the isolation of seven compounds showing strong anti-platelet… Expand
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References

SHOWING 1-10 OF 19 REFERENCES
Dimeric 2-quinolone alkaloid and antiplatelet aggregation constituents of Zanthoxylum simulans
Abstract A new dimeric 2-quinolone alkaloid, zanthobisquinolone, together with 15 known compounds, has been isolated from the root wood of Zanthoxylum simulans. On the basis of spectral analyses, theExpand
Toddaquinoline from formosan Toddalia asiatica
Abstract From the tertiary basic fraction of the root bark of Formosan Toddalia asiatica , a new benzo[h]quinoline alkaloid, toddaquinoline, together with six alkaloids and six coumarins wereExpand
Coumarins and anti-platelet aggregation constituents from Zanthoxylum schinifolium.
TLDR
Seven compounds with strong inhibitory activity on platelet aggregation in vitro were isolated from the chloroform-soluble part of the bark of Zanthoxylum schinifolium by bioassay-guided fractionation. Expand
N-Cyclohexyl amides and a dimeric coumarin from formosan Toddalia asiatica
Abstract Examination of the root wood of Formosan Toddalia asiatica led to the isolation of four N -cyclohexylamides: N , N ′-dicyclohexyloxamide, N , N ′-dicyclohexylurea, toddaliamide,Expand
Nor-neolignan and phenyl propanoid from Zanthoxylum ailanthoides
Abstract From the chloroform-soluble fraction of stem woods of Zanthoxylum ailanthoides , one new nor-neolignan, ailanthoidol, and one new phenyl propanoid, ailanthoidiol, together with nineExpand
Coumarins and antiplatelet aggregation constituents from Formosan Peucedanum japonicum.
TLDR
Seven compounds, eugenin, (-)-selinidin, (+)-pteryxin, imperatorin, bergapten, cnidilin and (+)-visamminol, show strong antiplatelet aggregation activity in vitro. Expand
Derivate des Methylendioxybenzols, 40. Synthese des Ferrugons und des Pseudoferrugons
Die Isoflavone Ferrugon (1a) und Pseudoferrugon (1b) sowie die Dihydroverbindungen 2a und b werden durch Reaktion der Apionderivate5f und 6f mit den Chromen- bzw. Chroman-derivaten 4d bzw. 36pExpand
Mass spectra and proton magnetic resonance spectra of some tetrahydroprotoberberine alkaloids
The mass spectra and the proton magnetic resonance spectra of tetrahydroprotoberberine alkaloids, oxygenated at the 9- and 10-positions, show marked differences from the spectra of those oxygenatedExpand
Inhibition of wheat embryo calcium-dependent protein kinase by acridines and azaacridines.
TLDR
The inhibition of wheat Ca(2+)-dependent protein kinase (CDPK) by substituted acridines and substituted 5, 6, 7- and 8-azaacridines was examined and may be useful in obtaining evidence for CDPK involvement in plant cell responses to specific signals. Expand
1HNMR Chemical Shift Values for Aromatic Protons in 2,3,9,10- and 2,3,10,11-tetrasubstituted Tetrahydroprotoberberine Alkaloids.
The (1)HNMR (CDCl (3)) data on 28 tetrahydroprotoberberine alkaloids have shown that it is possible, from the chemical shift values observed for the aromatic protons, not only to determine theExpand
...
1
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