Anti-plasmodial activity of Ailanthus excelsa.

  title={Anti-plasmodial activity of Ailanthus excelsa.},
  author={Mario Dell'Agli and Germana V Galli and Silvia Parapini and Nicoletta Basilico and Donatella Taramelli and Ataa Said and Khaled E. Rashed and Enrica Bosisio},
  volume={79 2},
The anti-plasmodial activity of Ailanthus excelsa stem bark was investigated. The methanolic extract inhibited in vitro growth of chloroquine-sensitive (D10) and resistant strains (W2) of Plasmodium falciparum (IC50 4.6 and 2.8 microg/ml, respectively). The effect was retained in the chloroform fraction (3.1 and 2.1 microg/ml, respectively). The anti-plasmodial activity could be ascribed to the impairment of haemoglobin degradation through the inhibition of plasmepsin II activity (IC50 of 13.43… CONTINUE READING


Publications referenced by this paper.
Showing 1-3 of 3 references

Lloydia 1977;40:579

M Ogura, GA Cordell, AD Kinghorn, NR. Farnsworth
Fitoterapia • 2008
View 1 Excerpt

Pharmacol Ther 1999;81:91

PL Olliaro, Y. Yuthavong
View 1 Excerpt

Anal Biochem 1976;72:248

MM Bradford

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