Anti-plasmodial activity of Ailanthus excelsa.

@article{DellAgli2008AntiplasmodialAO,
  title={Anti-plasmodial activity of Ailanthus excelsa.},
  author={Mario Dell'Agli and Germana V Galli and Silvia Parapini and Nicoletta Basilico and Donatella Taramelli and Ataa Said and Khaled E. Rashed and Enrica Bosisio},
  journal={Fitoterapia},
  year={2008},
  volume={79 2},
  pages={112-6}
}
The anti-plasmodial activity of Ailanthus excelsa stem bark was investigated. The methanolic extract inhibited in vitro growth of chloroquine-sensitive (D10) and resistant strains (W2) of Plasmodium falciparum (IC50 4.6 and 2.8 microg/ml, respectively). The effect was retained in the chloroform fraction (3.1 and 2.1 microg/ml, respectively). The anti-plasmodial activity could be ascribed to the impairment of haemoglobin degradation through the inhibition of plasmepsin II activity (IC50 of 13.43… CONTINUE READING

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