Corpus ID: 36987125

Anti-peptide antibodies recognize anti-substance P antibodies in an idiotypic fashion.

@article{Pascual1989AntipeptideAR,
  title={Anti-peptide antibodies recognize anti-substance P antibodies in an idiotypic fashion.},
  author={David W Pascual and Kenneth L. Bost},
  journal={Peptide research},
  year={1989},
  volume={2 3},
  pages={
          207-12
        }
}
  • David W Pascual, Kenneth L. Bost
  • Published in Peptide research 1989
  • Medicine
  • A peptide (AGFGVVKKPNY) was synthesized based on an RNA sequence complementary to the mRNA encoding substance P (Sub P). Antibodies against this Sub P complementary peptide (termed anti-C Pep antibodies) were produced by immunizing rats with peptide conjugated to the carrier protein, keyhole limpet hemocyanin. Antisera were then passed over a peptide conjugated affinity column to specifically purify the anti-C Pep antibodies. In a similar manner, anti-Sub P antibodies were produced in rabbits… CONTINUE READING

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