Anti-parasitic Guanidine and Pyrimidine Alkaloids from the Marine Sponge Monanchora arbuscula.

  title={Anti-parasitic Guanidine and Pyrimidine Alkaloids from the Marine Sponge Monanchora arbuscula.},
  author={Mario F.C. Santos and Philip M Harper and David E. Williams and Juliana Tonini Mesquita and {\'E}rika Gracielle Pinto and Thais Alves da Costa-Silva and Eduardo Hajdu and Antonio Gilberto Ferreira and Raquel Alves Dos Santos and Patrick J. Murphy and Raymond J. Andersen and Andr{\'e} Gustavo Tempone and Roberto G. S. Berlinck},
  journal={Journal of natural products},
  volume={78 5},
HPLC-UV-ELSD-MS-guided fractionation of the anti-parasitic extract obtained from the marine sponge Monanchora arbuscula, collected off the southeastern coast of Brazil, led to the isolation of a series of guanidine and pyrimidine alkaloids. The pyrimidines monalidine A (1) and arbusculidine A (7), as well as the guanidine alkaloids batzellamide A (8) and hemibatzelladines 9-11, represent new minor constituents that were identified by analysis of spectroscopic data. The total synthesis of… 
Cytotoxic Guanidine Alkaloids from a French Polynesian Monanchora n. sp. Sponge.
Four bicyclic and three pentacyclic guanidine alkaloids (1-7) were isolated from a French Polynesian Monanchora n. sp. sponge, along with the known alkaloids monalidine A (8), enantiomers 9-11 of
Chemical and Biological Aspects of Marine Sponges from the Family Mycalidae.
The pyrrole alkaloids and the cyclic peroxides appear to be phylogenetically restricted to sponges and thus might prove useful when applied to sponge taxonomy and thus make a good target for targeted biodiscovery projects.
Identification of Fromiamycalin and Halaminol A from Australian Marine Sponge Extracts with Anthelmintic Activity against Haemonchus contortus
There is an urgent need to discover and develop new anthelmintics for the treatment of parasitic nematodes of veterinary importance to circumvent challenges linked to drug resistant parasites. Being
Ergosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria
The selection of naturally antiparasitic secondary metabolites in basidiomycetes, such as ergosterol, may provide potential scaffolds for drug design studies against neglected diseases.
Water-Soluble Glutamic Acid Derivatives Produced in Culture by Penicillium solitum IS1-A from King George Island, Maritime Antarctica.
The results indicated that the investigation of water-soluble natural products represents a relevant strategy in finding new secondary metabolites, and the new structures reported for 1-6 indicate that this strategy is a relevant Strategy.
Natural Products from Sponges
Development of recombinant microorganisms engineered for efficient production of sponge-derived products is a promising strategy that deserves further attention in future investigations in order to address the limitations regarding sustainable supply of marine drugs.
Naturally Occurring Alkaloids, Derivatives, and Semi-synthetic Modifications as Lead Compounds for the Development of New Anti-Trypanosoma cruzi Agents
According to the available data, there are a good number of promising natural and/or semi-synthetic alkaloids that would meet the criteria to become candidates in the drug discovery process against Trypanosoma cruzi parasites.
Batzella, Crambe and Monanchora: Highly Prolific Marine Sponge Genera Yielding Compounds with Potential Applications for Cancer and Other Therapeutic Areas
This review comprehensively covers the chemodiversity and the bioactivities landmarks centered around the chemical constituents exclusively isolated from these three marine genera including Batzella, Crambe and Monanchora over the period 1981–2017, paying a special attention to the polycyclic guanidinic compounds and their proposed biomimetic landmarks.
Short‐Cut Bio‐Inspired Synthesis of Tricyclic Guanidinic Motifs of Crambescidins and Batzelladines Marine Alkaloids
: We report a convenient short synthesis of tricyclic guanidine-containing natural products model featuring four-component reaction between 2,5-dimethoxytetrahydrofuran, 2-aminopyrimidine and two


Netamines H-N, tricyclic alkaloids from the marine sponge Biemna laboutei and their antimalarial activity.
Seven new tricyclic alkaloids, netamines H-N (1-7), along with the known netamine G and mirabilins A, C, and F, are isolated from the Madagascar sponge Biemna laboutei for their cytotoxicity against KB cells and their antiplasmodial activity.
Three new tricyclic guanidine alkaloids from the sponge Batzella sp.
During the large-scale isolation of the batzelladines A and B, which are inhibitors of gp120-CD4 binding, the structures and relative stereochemistry of these compounds were determined by spectral analysis and by comparison with spectral data of ptilocaulin.
Crambescidin 826 and dehydrocrambine A: new polycyclic guanidine alkaloids from the marine sponge Monanchora sp. that inhibit HIV-1 fusion.
Two new polycyclic guanidine alkaloids were isolated from the marine sponge Monanchora sp.
Antiprotozoan activity of Brazilian marine cnidarian extracts and of a modified steroid from the octocoral Carijoa riisei
The results indicate the potential of cnidarian natural compounds as antileishmanial drug candidates, and a modified steroid isolated from the octocoral Carijoa riisei is evaluated.
Antimicrobial metabolites from the Paracel Islands sponge Agelas mauritiana.
Four new alkaloids isolated from the marine sponge Agelas mauritiana showed antifungal activity against Cryptococcus neoformans and antileishmanial activity against Leishmania donovani in vitro and exhibited antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aUREus in vitro.
Manadoperoxides, a new class of potent antitrypanosomal agents of marine origin.
Interestingly, it appears that minor structural changes, such as a shift of the methyl group around the dioxane ring, can dramatically affect the antitrypanosomal activity.
Alkaloids from the sponge Monanchora unguifera.
The bioassay-guided fractionation of the cytotoxic crude gum obtained from the Caribbean sponge Monanchora unguifera led to the isolation and characterization of the new compounds batzelladine J (1)