Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance

  title={Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance},
  author={Th{\'e}o Ara{\'u}jo-Santos and Bruno Bezerril Andrade and Leonardo Gil-Santana and N{\'i}vea Farias Luz and Priscila Lima dos Santos and Fabr{\'i}cia Alvisi de Oliveira and Meirielly Lima Almeida and Roseane Nunes de Santana Campos and Patr{\'i}cia Torres Bozza and Roque P Almeida and Val{\'e}ria Matos Borges},
  booktitle={Scientific Reports},
Visceral leishmaniasis (VL) remains a major public health problem worldwide. Cytokine balance is thought to play a critical role in the development of this disease. Here, we perform a prospective exploratory study addressing whether simultaneous assessment of circulating levels of different lipid mediators and cytokines could highlight specific pathways involved with VL pathogenesis. VL patients displayed substantial increases in serum levels of Prostaglandin F2α (PGF2α), Leukotriene B4 (LTB4… CONTINUE READING
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