Anti-pancreatic cancer effects of a polar extract from the edible sea cucumber, Cucumaria frondosa.

@article{Roginsky2010AntipancreaticCE,
  title={Anti-pancreatic cancer effects of a polar extract from the edible sea cucumber, Cucumaria frondosa.},
  author={Alexandra B Roginsky and X. Ding and Carl Woodward and Michael Ujiki and Brahmchetna Singh and Richard H. Bell and Peter Collin and Thomas Edward Adrian},
  journal={Pancreas},
  year={2010},
  volume={39 5},
  pages={646-52}
}
OBJECTIVES To investigate the effects and mechanism of Frondanol-A5P, a polar extract from Cucumaria frondosa, on growth inhibition and apoptosis in S2013 and AsPC-1 human pancreatic cancer cells. METHODS The effects of Frondanol-A5P on proliferation, cell cycle, expression of cell cycle proteins and p21, phosphorylation of MAP kinases, annexin V binding, and caspase-3 activation were examined. RESULTS Frondanol-A5P inhibited proliferation and induced G2/M phase cell cycle arrest in both… CONTINUE READING
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