Anti-oxidant effect of heme oxygenase-1 on cigarette smoke-induced vascular injury

  title={Anti-oxidant effect of heme oxygenase-1 on cigarette smoke-induced vascular injury},
  author={Genhuan Yang and Yanchuan Li and Wei Wu and Bao Liu and Leng Ni and Zhanqi Wang and Shiying Miao and Linfang Wang and Changwei Liu},
  booktitle={Molecular medicine reports},
Cigarette smoking, a major independent risk factor of atherosclerosis, can cause oxidative and inflammatory damage of vascular tissue. Heme oxygenase-1 (HO-1) is an endogenous cytoprotective enzyme with an anti-oxidant role in cells. The aim of the present study was to investigate whether HO-1 was able to protect vascular and endothelial cells from the oxidative damage induced by cigarette smoking. It was observed that cigarette smoking was able to induce the generation of the reactive oxygen… CONTINUE READING


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