Anti-oxidant and anti-inflammatory activities of macelignan in murine hippocampal cell line and primary culture of rat microglial cells.

@article{Jin2005AntioxidantAA,
  title={Anti-oxidant and anti-inflammatory activities of macelignan in murine hippocampal cell line and primary culture of rat microglial cells.},
  author={Da-qing Jin and Chol Seung Lim and Jae Kwan Hwang and Ilho Ha and J Han},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={331 4},
  pages={1264-9}
}
Epidemiological studies suggest that the treatments of anti-inflammatory agents and anti-oxidants slow the progress of neurological diseases. Lignans are anti-oxidants and phytoestrogens found in a variety of plants. In this study, we investigated the neuroprotective effect of macelignan on glutamate-induced neurotoxicity and reactive oxygen species (ROS) in murine hippocampal HT22 cell line. Macelignan significantly attenuated the ROS production and neurotoxicity induced by glutamate in HT22… CONTINUE READING
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