Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin.

@article{Seelinger2008AntioxidantAA,
  title={Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin.},
  author={G{\"u}nter Seelinger and Irmgard Merfort and C M Schempp},
  journal={Planta medica},
  year={2008},
  volume={74 14},
  pages={
          1667-77
        }
}
Luteolin is a flavone which occurs in medicinal plants as well as in some vegetables and spices. It is a natural anti-oxidant with less pro-oxidant potential than the flavonol quercetin, the best studied flavonoid, but apparently with a better safety profile. It displays excellent radical scavenging and cytoprotective properties, especially when tested in complex biological systems where it can interact with other anti-oxidants like vitamins. Luteolin displays specific anti-inflammatory effects… Expand
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References

SHOWING 1-10 OF 102 REFERENCES
Evaluation of the anti-inflammatory activity of luteolin in experimental animal models.
TLDR
The results derived from the whole blood assay for cyclooxygenase (COX) and the reverse transcription-polymerase chain reaction (RT-PCR) assay indicate that luteolin may be a potent selective inhibitor of cyclo oxygengenase-2 (COx-2) and that the inhibition is attributable to its down-regulation of the mRNA expression of COX-2 in inflammatory responses. Expand
Flavonoids and related compounds as anti-allergic substances.
TLDR
It is expected that a dietary menu including an appropriate intake of flavonoids may provide a form of complementary and alternative medicine and a preventative strategy for allergic diseases. Expand
Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens.
TLDR
Results suggest that luteolin is a genuinely active constituent which is accountable for the oral effects of perilla, and the inhibitory activity of TNF-alpha production in vitro is used as the index for isolation. Expand
Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships.
TLDR
The diversity and multiple mechanisms of flavonoid action, together with the numerous methods of initiation, detection and measurement of oxidative processes in vitro and in vivo offer plausible explanations for existing discrepancies in structure-activity relationships. Expand
Luteolin-rich artichoke extract protects low density lipoprotein from oxidation in vitro.
TLDR
The results demonstrate that the antioxidant activity of the artichoke extract relates in part to its constituent flavonoids which act as hydrogen donors and metal ion chelators, and the effectiveness is further influenced by their partitioning between aqueous and lipophilic phases. Expand
Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW264.7 cells
  • Chun Hu, D. Kitts
  • Chemistry, Medicine
  • Molecular and Cellular Biochemistry
  • 2004
TLDR
Luteolin and luteolin-7-O-glucoside at concentrations lower than 20 μM, significantly suppressed the productions of nitric oxide and prostaglandin E2 in bacterial lipopolysaccharide activated-mouse macrophage RAW264.7 cells without introducing cytotoxicity. Expand
A Hydroxyl Group of Flavonoids Affects Oral Anti-inflammatory Activity and Inhibition of Systemic Tumor Necrosis Factor-α Production
TLDR
The results suggest that the structure of luteolin: 3′,4′,5,7-tetrahydroxyflavone, is most suitable for the oral anti-inflammatory activity and that existence or disappearance of a hydroxy group may cause a loss of efficiency. Expand
Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship.
TLDR
It is demonstrated that most of the flavonoids assayed reduce macrophage M-CSF-induced proliferation without affecting cellular viability and some flavonoid also inhibit TNFalpha production as well as iNOS expression and NO production in LPS-activated macrophages, an effect that has been associated with the inhibition of the NF-kappaB pathway. Expand
Effects of luteolin and other flavonoids on IgE-mediated allergic reactions.
TLDR
From results, luteolin inhibited the IgE-mediated biphasic cutaneous reaction mainly by the inhibition of histamine and cytokine release from mast cells, but not through mediator antagonistic effects. Expand
Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor alpha.
TLDR
New aspects of regulatory mechanisms by which flavonoids suppress production of tumor necrosis factor-alpha by macrophages, microglial cells and mast cells stimulated with lipopolysaccharide and others via toll-like receptors (TLRs), and TNF-alpha-mediated acute and chronic inflammatory responses are described. Expand
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