Anti-oestrogenic prevention of breast cancer — the make or break point

@article{Powles2002AntioestrogenicPO,
  title={Anti-oestrogenic prevention of breast cancer — the make or break point},
  author={Trevor J. Powles},
  journal={Nature Reviews Cancer},
  year={2002},
  volume={2},
  pages={787-794}
}
Clinical trials have shown that giving anti-oestrogens to healthy women can reduce the early incidence of breast cancer by ∼40%. However, the large numbers of women treated, compared with the few who get breast cancer, together with the not insignificant toxicity and the unknown long-term clinical benefits and risks, makes this strategy of prevention versus treatment precarious. So how can we improve the odds for the successful use of endocrine chemoprevention? 
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