Anti-obesity effect of phenylcoumarins from two Calophyllum spp in 3T3-L1 adipocytes

@article{Thiagarajan2017AntiobesityEO,
  title={Anti-obesity effect of phenylcoumarins from two Calophyllum spp in 3T3-L1 adipocytes},
  author={Siroshini Thiagarajan and F. Yong and Hemaroopini Subramaniam and V. Jong and C. Lim and Y. Say},
  journal={Tropical Journal of Pharmaceutical Research},
  year={2017},
  volume={16},
  pages={563-572}
}
Purpose : To evaluate the anti-obesity effects of five compounds isolated from Calophyllum andersonnii and Calophyllum sclerophyllum, viz, friedelin (CP1), friedelinol (CP2), isodispar B (CP3), 5,7-dihydroxy-6-(3-methybutyryl)-4-phenylcoumarin (CP4) and 5,7-dihydroxy-6-(2-methybutyryl)-4-phenylcoumarin (CP5) in 3T3-L1 mouse pre-adipocytes. Methods: Maximum non-toxic doses (MNTDs) of CP1 - CP5 were obtained by conducting 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay… Expand