Anti-obesity Effect of (8-E)-Nüzhenide, a Secoiridoid from Ligustrum lucidum, in High-fat Diet-induced Obese Mice

@article{Liu2014AntiobesityEO,
  title={Anti-obesity Effect of (8-E)-N{\"u}zhenide, a Secoiridoid from Ligustrum lucidum, in High-fat Diet-induced Obese Mice},
  author={Qing Liu and Sang Hyun Kim and Seon B. Kim and Yang Hee Jo and Eun Sil Kim and Bang Yeon Hwang and Kyunghee Oh and Mi Kyeong Lee},
  journal={Natural Product Communications},
  year={2014},
  volume={9}
}
The effect of the extract of Ligustrum lucidum fruits (LFE) and its major secoiridoid (LFS), (8-E)-nüzhenide, on obesity was investigated using high fat-diet (HFD)-induced C58BL/6J obese mice. LFE and LFS were administered at the doses of 300 mg/kg and 30 mg/kg, respectively, for 6 weeks. The anti-obesity activity was evaluated by measuring body weight, epididymal fat and metabolic plasma parameters. On Day 42, the body weight of the LFS-treated group was significantly lower compared with the… CONTINUE READING

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