Anti-nitric oxide production activity of isothiocyanates correlates with their polar surface area rather than their lipophilicity.

Abstract

There is increasing demand for novel anti-inflammatory drugs with different mechanisms of action. We synthesized a series of isothiocyanates 2b-h based on 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) found in the pungent spice Wasabia japonica. Inhibitory activities against in-vitro growth of tumor cells and production of nitric oxide (NO) using the… (More)
DOI: 10.1016/j.ejmech.2009.08.005

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