Anti-neutrophil cytoplasmic autoantibodies (ANCA): antigenic specificities and clinical associations.

  title={Anti-neutrophil cytoplasmic autoantibodies (ANCA): antigenic specificities and clinical associations.},
  author={Xavier Bosch and J Font and Eduard Mirapeix and Lu{\'i}s Revert and Alvaro Urbano-M{\'a}rquez and Miguel Ingelmo},
  journal={Advances in experimental medicine and biology},
We have conducted a prospective study of 372 patients with well-defined forms of systemic vasculitis and connective tissue diseases to determine the prevalence, the antigenic specificities and the clinical associations of ANCA in such cases. These antibodies were detected by indirect immunofluorescence on ethanol-fixed neutrophils and also by enzyme-linked immunosorbent assay using myeloperoxidase (MPO) as a substrate. In our study, ANCA with a cytoplasmic immunostaining pattern were mainly… CONTINUE READING
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