Anti-neuropilin-1 peptide inhibition of synoviocyte survival, angiogenesis, and experimental arthritis.

@article{Kong2010Antineuropilin1PI,
  title={Anti-neuropilin-1 peptide inhibition of synoviocyte survival, angiogenesis, and experimental arthritis.},
  author={Jin-Sun Kong and Seung-ah Yoo and Jung-Wook Kim and Seung-pil YANG and C Chae and V Tarallo and S De Falco and S. Ryu and C Cho and W. Kim},
  journal={Arthritis and rheumatism},
  year={2010},
  volume={62 1},
  pages={179-90}
}
OBJECTIVE To delineate the role of neuropilin-1 (NP-1), a vascular endothelial growth factor receptor (VEGFR), in rheumatoid inflammation and to determine whether blockade of NP-1 could suppress synoviocyte survival and angiogenesis. METHODS VEGF(111-165) peptide, which encompasses the NP-1 binding domain of VEGF(165), was generated by cleaving VEGF(165) with plasmin. The effect of this peptide on the interaction between VEGF(165) and its receptor was determined by (125)I-VEGFR binding assay… CONTINUE READING

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