Anti-neuronal antibodies in paraneoplastic neurological disorders with small-cell lung carcinoma.

@article{Moll1990AntineuronalAI,
  title={Anti-neuronal antibodies in paraneoplastic neurological disorders with small-cell lung carcinoma.},
  author={J. W. B. Moll and Sonja C. Henzen-Logmans and Charles J. Vecht},
  journal={Clinical neurology and neurosurgery},
  year={1990},
  volume={92 3},
  pages={223-8}
}
Auto-antibodies of the neuronal anti-nuclear antibody (anti-Hu) type were found in serum of three patients suspected of a paraneoplastic syndrome of the central nervous system. In all three a small cell carcinoma of the lung was detected. The sera showed bright staining of neuronal nuclei sparing the nucleolus. In two patients the antibody was of the IgG class (titers 1:1600 and 1:4000). In one patient only an IgM class antibody was present (titer 1:1000). The presence of the anti-Hu antibody… CONTINUE READING