Anti-neural antibodies in serum and cerebrospinal fluid of amyotrophic lateral sclerosis (ALS) patients.

@article{NiebrojDobosz1999AntineuralAI,
  title={Anti-neural antibodies in serum and cerebrospinal fluid of amyotrophic lateral sclerosis (ALS) patients.},
  author={Irena Maria Niebroj-Dobosz and Zygmunt Jamrozik and Piotr Janik and Irena Hausmanowa-Petrusewicz and Hubert Kwiecinski},
  journal={Acta neurologica Scandinavica},
  year={1999},
  volume={100 4},
  pages={238-43}
}
OBJECTIVES An autoimmune basis has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). This hypothesis is supported by the presence of antibodies that interact with motoneuron antigens in serum of these patients. Against autoimmunity are the discrepances in the frequency of the antibodies appearance and also failure of immunosuppression. The aim of our study was to evaluate the titer of antibodies against GM1-gangliosides, AGM1-gangliosides and anti-sulfatides in paired… CONTINUE READING

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