Anti-neoplastic properties of hydralazine in prostate cancer

  title={Anti-neoplastic properties of hydralazine in prostate cancer},
  author={In{\^e}s Graça and Elsa Joana Sousa and Pedro Costa-Pinheiro and Filipa Quintela Vieira and Jorge Torres-Ferreira and Maria Gabriela Martins and Rui Henrique and Carmen Jer{\'o}nimo},
Prostate cancer (PCa) is a major cause of cancer-related morbidity and mortality worldwide. Although early disease is often efficiently managed therapeutically, available options for advanced disease are mostly ineffective. Aberrant DNA methylation associated with gene-silencing of cancer-related genes is a common feature of PCa. Therefore, DNA methylation inhibitors might constitute an attractive alternative therapy. Herein, we evaluated the anti-cancer properties of hydralazine, a non… CONTINUE READING