Anti-mu-opioid-receptor IgG antibodies are commonly present in serum from healthy blood donors: evidence for a role in apoptotic immune cell death.

@article{Mac2002AntimuopioidreceptorIA,
  title={Anti-mu-opioid-receptor IgG antibodies are commonly present in serum from healthy blood donors: evidence for a role in apoptotic immune cell death.},
  author={Ga{\"e}tane Mac{\'e} and Martial Jaume and Catherine Blanpied and Lionel Stephan and Jerome D Coudert and Philippe Druet and Gilles Dietrich},
  journal={Blood},
  year={2002},
  volume={100 9},
  pages={3261-8}
}
We previously observed the presence of anti-human mu-opioid-receptor (anti-hMOR) autoantibodies in IgG pools prepared from several thousand healthy blood donors. These autoantibodies behaved agonistically because of their ability to bind to the first and third extracellular loops of the receptor. In this study, we found that each healthy donor's serum contained anti-hMOR IgG autoantibodies with a specific activity against both the first and the third extracellular loops of the receptor. Because… CONTINUE READING

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