Anti-mouse mesangial cell serum induces acute glomerulonephropathy in mice.

@article{Yo2003AntimouseMC,
  title={Anti-mouse mesangial cell serum induces acute glomerulonephropathy in mice.},
  author={Yoshikage Yo and Michael C Braun and Laura M C Barisoni and Hideko Mobaraki and Huiyan Lu and Shashi Shrivastav and Jennie Owens and Jeffrey B. Kopp},
  journal={Nephron. Experimental nephrology},
  year={2003},
  volume={93 3},
  pages={e92-106}
}
In order to develop a model in mouse similar to anti- Thy-1 nephritis in the rat, we prepared sheep antiserum against SV40-transformed mouse mesangial (MES 13) cells. In vivo, the anti-mouse mesangial cell serum-treated mice showed severe azotemia that peaked at day 6 and proteinuria that peaked at day 8, in a dose-dependent fashion. Light microscopy and electron microscopy showed duplication of glomerular basement membranes, mesangiolysis, subendothelial and mesangial electron-dense deposits… CONTINUE READING