Anti-mosquito midgut antibodies block development of Plasmodium falciparum and Plasmodium vivax in multiple species of Anopheles mosquitoes and reduce vector fecundity and survivorship.

@article{Lal2001AntimosquitoMA,
  title={Anti-mosquito midgut antibodies block development of Plasmodium falciparum and Plasmodium vivax in multiple species of Anopheles mosquitoes and reduce vector fecundity and survivorship.},
  author={Altaf A. Lal and Paige Patterson and John B. Sacci and Jefferson A Vaughan and Chris W. Paul and William E. Collins and Robert Andrew Wirtz and A. F. Azad},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 9},
  pages={5228-33}
}
The mosquito midgut plays a central role in the sporogonic development of malaria parasites. We have found that polyclonal sera, produced against mosquito midguts, blocked the passage of Plasmodium falciparum ookinetes across the midgut, leading to a significant reduction of infections in mosquitoes. Anti-midgut mAbs were produced that display broad-spectrum activity, blocking parasite development of both P. falciparum and Plasmodium vivax parasites in five different species of mosquitoes. In… CONTINUE READING
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