Anti-modified LDL antibodies, LDL-containing immune complexes, and susceptibility of LDL to in vitro oxidation in patients with type 2 diabetes.

@article{Mironova2000AntimodifiedLA,
  title={Anti-modified LDL antibodies, LDL-containing immune complexes, and susceptibility of LDL to in vitro oxidation in patients with type 2 diabetes.},
  author={Margarita Anatolyevna Mironova and Richard L. Klein and Gabriel Virella and Maria F. Lopes-Virella},
  journal={Diabetes},
  year={2000},
  volume={49 6},
  pages={1033-41}
}
We investigated the hypothesis that modified lipoproteins trigger an immune response leading to the production of autoantibodies and subsequently to the formation of atherogenic immune complexes (IC). We recruited 20 type 2 diabetic patients with macrovascular disease, 14 nondiabetic patients with coronary artery disease (CAD), and 34 healthy control subjects matched for age, sex, and race. Serum antibodies to oxidized and glycated LDL did not differ significantly among the 3 groups. Serum IC… CONTINUE READING