Anti-mitogenic action of opioid peptides on epidermal growth factor-stimulated uterine cells.

@article{Krnyei2001AntimitogenicAO,
  title={Anti-mitogenic action of opioid peptides on epidermal growth factor-stimulated uterine cells.},
  author={J{\'o}zsef L. K{\"o}rnyei and Ang{\'e}la Oszter and Katherine A Kovacs and Zsuzsanna V{\'e}rtes and Katalin Komlosi and P{\'e}ter Mikl{\'o}s G{\"o}cze and Marietta V{\'e}rtes},
  journal={European journal of pharmacology},
  year={2001},
  volume={414 2-3},
  pages={
          155-63
        }
}
Endogenous opioid peptides are negative regulators of estradiol-induced uterine cell proliferation. To investigate the possible molecular target site(s) of their anti-mitogenic action, we examined the effect of opioid peptides on epidermal growth factor-induced cell proliferation both in uterine primary cell cultures prepared from adult rats and in human myometrial smooth muscle cell lines. Epidermal growth factor (EGF) significantly increased cell density in both types of cultured monolayers… CONTINUE READING

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