Anti-miR-21 oligonucleotide sensitizes leukemic K562 cells to arsenic trioxide by inducing apoptosis.

@article{Li2010AntimiR21OS,
  title={Anti-miR-21 oligonucleotide sensitizes leukemic K562 cells to arsenic trioxide by inducing apoptosis.},
  author={Yumin Li and Xuejiao Zhu and Jingyi Gu and Dawei W. Dong and Junlin Yao and Chunyan Lin and Kangkang Huang and Jia Fei},
  journal={Cancer science},
  year={2010},
  volume={101 4},
  pages={
          948-54
        }
}
Arsenic trioxide (ATO), an ancient traditional Chinese medicine, has been successfully used as a therapeutic agent for leukemia. Drug resistance and toxicity are major concerns with the treatment. MicroRNAs (miRNAs) are endogenous small non-coding RNA molecules that might modulate cellular sensitivity to anticancer drugs. miRNA-21 (miR-21) is one of the most prominent miRNAs involved in various aspects of human cancers. However, miR-21 has been rarely characterized in chronic myelogenous… CONTINUE READING

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