Anti-metastatic activities of bibenzyls from Dendrobium pulchellum.

@article{Chanvorachote2013AntimetastaticAO,
  title={Anti-metastatic activities of bibenzyls from Dendrobium pulchellum.},
  author={Pithi Chanvorachote and Akkarawut Kowitdamrong and Thidarat Ruanghirun and Boonchoo Sritularak and Chutichot Mungmee and Kittisak Likhitwitayawuid},
  journal={Natural product communications},
  year={2013},
  volume={8 1},
  pages={115-8}
}
Our investigation of the stem of Dendrobium pulchellum resulted in the isolation of four known bibenzyls, chrysotobibenzyl (1), chrysotoxine (2), crepidatin (3) and moscatilin (4). The present study reveals for the first time the ability of these four compounds to facilitate anoikis and inhibit the growth of lung cancer cells in anchorage-independent condition. The preliminary data obtained disclose the inhibitory effect on cancer cell metastasis of the isolated compounds, and provide an… CONTINUE READING

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