Anti-melanin deposition activity of ceramicines from Chisocheton ceramicus

  title={Anti-melanin deposition activity of ceramicines from Chisocheton ceramicus},
  author={Chie Iijima and Chin Piow Wong and Alfarius Eko Nugroho and Yayoi Sotozono and Saki Someya and Y. Hirasawa and T. Kaneda and A. H. Hadi and H. Morita},
  journal={Journal of Natural Medicines},
  • Chie Iijima, Chin Piow Wong, +6 authors H. Morita
  • Published 2016
  • Chemistry, Medicine
  • Journal of Natural Medicines
  • The ceramicines, a series of limonoids from Chisocheton ceramicus (Meliaceae), were evaluated for anti-melanin deposition activity on α-melanocyte stimulating hormone (α-MSH) and 3-isobutyl-1-methylxanthine (IBMX)-treated B16-F10 melanoma cell, and several ceramicines were found to be active. The structure–activity relationship of ceramicines as anti-melanin deposition inhibitors was deduced. Furthermore, the mechanism of anti-melanin deposition activity of ceramicine B, a major constituent of… CONTINUE READING
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