Anti-malarial efficacy of pyronaridine and artesunate in combination in vitro and in vivo.

@article{Vivas2008AntimalarialEO,
  title={Anti-malarial efficacy of pyronaridine and artesunate in combination in vitro and in vivo.},
  author={Livia Vivas and Lauren Rattray and Lindsay Stewart and Emily Bongard and Brian L. Robinson and Wallace Peters and Simon Croft},
  journal={Acta tropica},
  year={2008},
  volume={105 3},
  pages={222-8}
}
Pyronaridine is a Mannich base anti-malarial with demonstrated efficacy against drug resistant Plasmodium falciparum, P. vivax, P. ovale and P. malariae. However, resistance to pyronaridine can develop quickly when it is used alone but can be considerably delayed when it is administered with artesunate in rodent malaria models. The aim of this study was to evaluate the efficacy of pyronaridine in combination with artesunate against P. falciparum in vitro and in rodent malaria models in vivo to… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…