Anti-malarial and anti-inflammatory effects of gynura procumbens are mediated by kaempferol via inhibition of glycogen synthase kinase-3β (GSK3β)

  title={Anti-malarial and anti-inflammatory effects of gynura procumbens are mediated by kaempferol via inhibition of glycogen synthase kinase-3$\beta$ (GSK3$\beta$)},
  author={Kuan Wong Sok and Michelle S J Lee and Suhaini Binti Sudi and Wan Rozianoor Mohd Hassan and Ping-Chin Lee and Noor Embi and Hasidah Mohd. Sidek},
  journal={Sains Malaysiana},
Gynura procumbens is a medicinal plant, traditionally used to treat inflammation and fever. A yeast-based assay detected GSK3â-inhibitory activity in the aqueous extract of G. procumbens. GSK3â is now known to have a central role in the modulation of host inflammatory response during bacterial infections. In this study, we investigated the involvement of GSK3â in the anti-malarial and anti-inflammatory effects of an aqueous extract of G. procumbens. Our results showed that G. procumbens… Expand

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