Anti-lymphangiogenic properties of mTOR inhibitors in head and neck squamous cell carcinoma experimental models

@inproceedings{Ekshyyan2013AntilymphangiogenicPO,
  title={Anti-lymphangiogenic properties of mTOR inhibitors in head and neck squamous cell carcinoma experimental models},
  author={Oleksandr Y Ekshyyan and Tara N Moore-Medlin and Matthew C Raley and Kunal Sonavane and Xiaohua Rong and Michael A Brodt and Fleurette W. Abreo and J Steven Jonathan Alexander and Cherie-Ann O Nathan},
  booktitle={BMC Cancer},
  year={2013}
}
Tumor dissemination to cervical lymph nodes via lymphatics represents the first step in the metastasis of head and neck squamous cell carcinoma (HNSCC) and is the most significant predictor of tumor recurrence decreasing survival by 50%. The lymphatic suppressing properties of mTOR inhibitors are not yet well understood. Lymphatic inhibiting effects of rapamycin were evaluated in vitro using two lymphatic endothelial cell (LEC) lines. An orthotopic mouse model of HNSCC (OSC-19 cells) was used… CONTINUE READING
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