Anti-leishmanial activity of a new formulation of amphotericin B.

  title={Anti-leishmanial activity of a new formulation of amphotericin B.},
  author={Ma Auxiliadora Dea-Ayuela and Sara Rama-I{\~n}iguez and J. A. Sanchez-Brunete and Juan Jos{\'e} Torrado and Jos{\'e} M Alunda and Francisco Bol{\'a}s-Fern{\'a}ndez},
  journal={Tropical medicine & international health : TM & IH},
  volume={9 9},
The effectiveness of albumin microspheres loaded with amphotericin B was tested in an in vivo model of visceral leishmaniasis using the golden hamster. Free and encapsulated amphotericin B was tested at the dose of 1 mg/kg given by the intracardiac route on days 25, 26 and 27 post-infection (p.i.) to treat animals previously infected with 10(7) stationary promastigotes by the intracardiac route. Encapsulated amphotericin was highly effective against infection causing a reduction of 88.8% and 87… CONTINUE READING

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