Anti-latent TGF-beta binding protein-1 antibody or synthetic oligopeptides inhibit extracellular matrix expression induced by stretch in cultured rat mesangial cells.

@article{Hori1998AntilatentTB,
  title={Anti-latent TGF-beta binding protein-1 antibody or synthetic oligopeptides inhibit extracellular matrix expression induced by stretch in cultured rat mesangial cells.},
  author={Yusuke S Hori and Tetsuo Katoh and Michito Hirakata and Nicole Joki and Shinya Kaname and Masafumi Fukagawa and Toshihiro Okuda and Hiromi Ohashi and Takayuki Fujita and Kohei Miyazono and Kaneyuki Kurokawa},
  journal={Kidney international},
  year={1998},
  volume={53 6},
  pages={
          1616-25
        }
}
Transforming growth factor-beta (TGF-beta) is usually secreted as a large latent complex associated with latent TGF-beta binding protein-1 (LTBP-1), which is known to bind to extracellular matrix (ECM) components. Although the LTBP-ECM interaction has been suggested to play a role in the activation and biological action of TGF-beta, the precise mechanism is still unclear. In glomerular hypertension mesangial cells are believed to perceive the increased cyclic strain and we have recently… CONTINUE READING
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