Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina.

@article{Chaitman2004AntiischemicEA,
  title={Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina.},
  author={Bernard R. Chaitman and Sandra L. Skettino and John Orval Parker and Peter Hanley and Jaroslav Meluzin and Jerzy Kuch and Carl J Pepine and Whedy Wang and Jeanenne J. Nelson and David A. Hebert and Andrew A. Wolff},
  journal={Journal of the American College of Cardiology},
  year={2004},
  volume={43 8},
  pages={1375-82}
}
OBJECTIVES The primary objective of the Monotherapy Assessment of Ranolazine In Stable Angina (MARISA) trial was to determine the dose-response relationship of ranolazine, a potentially new anti-anginal compound, on symptom-limited exercise duration. BACKGROUND Fatty acids rise precipitously in response to stress, including acute myocardial ischemia. Ranolazine is believed to partially inhibit fatty acid oxidation, shift metabolism toward carbohydrate oxidation, and increase the efficiency of… CONTINUE READING

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