Anti-interleukin-6 receptor antibody prevents muscle atrophy in colon-26 adenocarcinoma-bearing mice with modulation of lysosomal and ATP-ubiquitin-dependent proteolytic pathways.

@article{Fujita1996Antiinterleukin6RA,
  title={Anti-interleukin-6 receptor antibody prevents muscle atrophy in colon-26 adenocarcinoma-bearing mice with modulation of lysosomal and ATP-ubiquitin-dependent proteolytic pathways.},
  author={Jiro Fujita and Toshimasa Tsujinaka and Masahiko Yano and Chikara Ebisui and Hideo Saito and Asao Katsume and Ken-ichi Akamatsu and Yoshiyuki Ohsugi and Hitoshi Shiozaki and Morito Monden},
  journal={International journal of cancer},
  year={1996},
  volume={68 5},
  pages={637-43}
}
Progression of skeletal muscle atrophy is one of the characteristic features in cancer patients. Interleukin-6 (IL-6) has been reported to be responsible for the loss of lean body mass during cancer cachexia in colon-26 adenocarcinoma (C-26)-bearing mice. This study was carried out to elucidate the intracellular proteolytic pathways operating in skeletal muscle in C-26-bearing mice, and to examine the effect of anti IL-6 receptor antibody on muscle atrophy. On day 17 after tumor inoculation… CONTINUE READING
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