Anti-interleukin 6 (IL-6) receptor antibody suppresses Castleman's disease like symptoms emerged in IL-6 transgenic mice.

@article{Katsume2002Antiinterleukin6,
  title={Anti-interleukin 6 (IL-6) receptor antibody suppresses Castleman's disease like symptoms emerged in IL-6 transgenic mice.},
  author={Asao Katsume and Hiroyuki Saito and Yoshiki Yamada and Keigo Yorozu and Otoya Ueda and Ken-ichi Akamatsu and Norihiro Nishimoto and Tadamitsu Kishimoto and Kazuyuki Yoshizaki and Yoshiyuki Ohsugi},
  journal={Cytokine},
  year={2002},
  volume={20 6},
  pages={304-11}
}
Transgenic mice carrying human IL-6 cDNA fused with a murine major histocompatibility class-I promoter (H-2L(d)) were serially administered with anti-interleukin-6 receptor (IL-6R) monoclonal antibody (mAb), MR16-1, from the age of 4 weeks to estimate its efficacy on a variety of disorders developed in these mice, most of which are similar to the disorders associated with Castleman's disease. In the control mice treated with isotype-matched mAb, a massive and multiple IgG1 plasmacytosis… CONTINUE READING

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