Anti-interleukin-31-antibodies ameliorate scratching behaviour in NC/Nga mice: a model of atopic dermatitis.

@article{Grimstad2009Antiinterleukin31antibodiesAS,
  title={Anti-interleukin-31-antibodies ameliorate scratching behaviour in NC/Nga mice: a model of atopic dermatitis.},
  author={Oystein Grimstad and Yasushi Sawanobori and Christian L. Vestergaard and Janine Bilsborough and Uffe Bang Olsen and Christian Gr\onh\oj-Larsen and Kouji Matsushima},
  journal={Experimental dermatology},
  year={2009},
  volume={18 1},
  pages={35-43}
}
BACKGROUND Interleukin-31 (IL-31), a novel cytokine, is upregulated in atopic dermatitis skin lesions in humans and skin lesions in the NC/Nga mice, a murine model for atopic dermatitis. OBJECTIVE Here, we investigated the effect of a monoclonal IL-31 antibody on scratching behaviour, weight gain and dermatitis in NC/Nga mice. METHODS Mice were divided into three groups, n = 10 in each group. Mice were given monoclonal IL-31 rat-anti-mouse antibody 10 mg/kg or albumin intraperitoneally… CONTINUE READING