Anti-interleukin-10 antibodies in patients with chronic active Epstein-Barr virus infection.

@article{Tanner1997Antiinterleukin10AI,
  title={Anti-interleukin-10 antibodies in patients with chronic active Epstein-Barr virus infection.},
  author={Jerome E. Tanner and Francisco Diaz-Mitoma and Cliona M Rooney and Caroline Alfieri},
  journal={The Journal of infectious diseases},
  year={1997},
  volume={176 6},
  pages={
          1454-61
        }
}
The Epstein-Barr virus (EBV) genome encodes a protein in its BamHI C restriction fragment rightward open-reading frame-1 (designated BCRF1 or viral interleukin-10 [vIL-10]) that shares protein homology and biologic properties with human IL-10. Several EBV disorders are characterized by prolonged active EBV infection. Because continued EBV replication could allow for increased vIL-10, ELISA and immunoprecipitation were used to determine whether vIL-10 expression during chronic active EBV… CONTINUE READING

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