Anti-interleukin-1 beta reduces sleep and sleep rebound after sleep deprivation in rats.

@article{Opp1994Antiinterleukin1BR,
  title={Anti-interleukin-1 beta reduces sleep and sleep rebound after sleep deprivation in rats.},
  author={Mark R. Opp and James M. Krueger},
  journal={The American journal of physiology},
  year={1994},
  volume={266 3 Pt 2},
  pages={R688-95}
}
Interleukin-1 (IL-1) is somnogenic and is hypothesized to be involved in physiological sleep regulation. Antibodies directed against rat IL-1 beta were used to further elucidate possible contributions of IL-1 to sleep regulation. Rabbit anti-rat IL-1 beta (anti-IL-1 beta) was injected intracerebroventricularly into normal rats 15 min before light onset. A 20-microgram dose of anti-IL-1 beta reduced non-rapid-eye-movement (NREM) sleep by 60 min during the subsequent 12-h slight period. There was… CONTINUE READING

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