Anti-interleukin-1β antibody prevents the occurrence of repeated restraint stress-induced alterations in synaptic transmission and long-term potentiation in the rat frontal cortex.

@article{Bobula2015Antiinterleukin1AP,
  title={Anti-interleukin-1β antibody prevents the occurrence of repeated restraint stress-induced alterations in synaptic transmission and long-term potentiation in the rat frontal cortex.},
  author={Bartosz Bobula and Joanna Sowa and Grzegorz Hess},
  journal={Pharmacological reports : PR},
  year={2015},
  volume={67 1},
  pages={123-8}
}
BACKGROUND The mechanisms of the influence of prolonged stress on glutamatergic transmission and synaptic plasticity in the cerebral cortex remain poorly understood. The purpose of this study was to determine an involvement of interleukin-1β (IL-1β) in the effects of repeated restraint stress on excitatory synaptic transmission and long-term potentiation (LTP) in the rat frontal cortex. METHODS The effects of restraint stress lasting for 10 min, repeated twice daily for 3 consecutive days… CONTINUE READING