Anti-influenza virus principles from Muehlenbeckia hastulata

  title={Anti-influenza virus principles from Muehlenbeckia hastulata},
  author={Takaaki Yasuda and Mitsuo Yamaki and Akiko Iimura and Yoshitaka Shimotai and Kazufumi Shimizu and Toshiro Noshita and Shinji Funayama},
  journal={Journal of Natural Medicines},
Extracts of Chilean medicinal plants were evaluated in vitro for their activities against influenza virus proliferation in MDCK cells. The most potent extract obtained was from Muehlenbeckia hastulata (Polygonaceae), known as Quilo in Chile, from which three active principles were isolated and identified as pheophorbide a (1), hypericin (2) and protohypericin (3). Minimum inhibitory concentration (MIC) values of 42 ng/ml for compound 1, 2.1 ng/ml for compound 2 and 1.5 ng/ml for the authentic… CONTINUE READING