Anti-influenza virus activity of peramivir in mice with single intramuscular injection.

@article{Bantia2006AntiinfluenzaVA,
  title={Anti-influenza virus activity of peramivir in mice with single intramuscular injection.},
  author={Shanta Bantia and C. S. Arnold and Cynthia D Parker and Ramanda T. Upshaw and Puran. Chand},
  journal={Antiviral research},
  year={2006},
  volume={69 1},
  pages={
          39-45
        }
}
In the event of an influenza outbreak, antivirals including the neuraminidase (NA) inhibitors, peramivir, oseltamivir, and zanamivir may provide valuable benefit when vaccine production is delayed, limited, or cannot be used. Here we demonstrate the efficacy of a single intramuscular injection of peramivir in the mouse influenza model. Peramivir potently inhibits the neuraminidase enzyme N9 from H1N9 virus in vitro with a 50% inhibitory concentration (IC(50)) of 1.3+/-0.4 nM. On-site… CONTINUE READING
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