Anti-inflammatory therapy by intravenous delivery of non-heparan sulfate-binding CXCL12

@article{Oboyle2009AntiinflammatoryTB,
  title={Anti-inflammatory therapy by intravenous delivery of non-heparan sulfate-binding CXCL12},
  author={Graeme O'boyle and Paul M. Mellor and John Andrew Kirby and Simi Ali},
  journal={The FASEB Journal},
  year={2009},
  volume={23},
  pages={3906 - 3916}
}
Interaction between chemokines and heparan sulfate (HS) is essential for leukocyte recruitment during inflammation. Previous studies have shown that a non-HS-binding mutant form of the inflammatory chemokine CCL7 can block inflammation produced by wild-type chemokines. This study examined the anti-inflammatory mechanism of a non-HS-binding mutant of the homeostatic chemokine CXCL12. Initial experiments demonstrated that mutant CXCL12 was an effective CXCR4 agonist. However, this mutant… CONTINUE READING
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